Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity

@inproceedings{Georgieva2018AntigenicVI,
  title={Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity},
  author={M Georgieva and Lisa Kagedan and Ying-jie Lu and Claudette M. Thompson and Marc Lipsitch},
  booktitle={mBio},
  year={2018}
}
Genomic analysis reveals extensive sequence variation and hot spots of recombination in surface proteins of Streptococcus pneumoniae While this phenomenon is commonly attributed to diversifying selection by host immune responses, there is little mechanistic evidence for the hypothesis that diversification of surface protein antigens produces an immune escape benefit during infection with S. pneumoniae Here, we investigate the biological significance of sequence variation within the S… CONTINUE READING
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