Antigenic Subversion: A Novel Mechanism of Host Immune Evasion by Ebola Virus

@inproceedings{Mohan2012AntigenicSA,
  title={Antigenic Subversion: A Novel Mechanism of Host Immune Evasion by Ebola Virus},
  author={Gopi S. Mohan and Wenfang Li and L Ye and Richard W. Compans and Chinglai Yang},
  booktitle={PLoS pathogens},
  year={2012}
}
In addition to its surface glycoprotein (GP(1,2)), Ebola virus (EBOV) directs the production of large quantities of a truncated glycoprotein isoform (sGP) that is secreted into the extracellular space. The generation of secreted antigens has been studied in several viruses and suggested as a mechanism of host immune evasion through absorption of antibodies and interference with antibody-mediated clearance. However such a role has not been conclusively determined for the Ebola virus sGP. In this… CONTINUE READING
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