Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy

@article{Wick1997AntigenicCC,
  title={Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy},
  author={Maresa Wick and Purnima Dubey and Hartmut Koeppen and Christopher T. Siegel and Patrick E. Fields and Lieping Chen and Jeffrey A Bluestone and Hans Schreiber},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={229 - 238}
}
One enigma in tumor immunology is why animals bearing malignant grafts can reject normal grafts that express the same nonself-antigen. An explanation for this phenomenon could be that different T cell clones react to the normal graft and the malignant cells, respectively, and only the tumor-reactive clonotypes may be affected by the growing tumor. To test this hypothesis, we used a T cell receptor transgenic mouse in which essentially all CD8(+) T cells are specific for a closely related set of… CONTINUE READING
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