Antigen-specific tolerance as a therapy for experimental autoimmune encephalomyelitis.

  title={Antigen-specific tolerance as a therapy for experimental autoimmune encephalomyelitis.},
  author={Stephen D Miller and Lalaine J. Tan and Louise J Pope and Bradford L. McRae and William J. Karpus},
  journal={International reviews of immunology},
  volume={9 3},
The effects of neuroantigen-specific tolerance on the induction and effector stages of EAE were examined. Tolerance induced by the i.v. injection of syngeneic splenocytes coupled with purified neuroantigens or encephalitogenic peptides of MBP and PLP using ethylene carbodiimide was extremely effective in both prevention and treatment of acute and relapsing forms of EAE in Lewis rats and SJL/J mice. The unresponsiveness is rapidly-induced, dose-dependent, long-lasting, efficient, MHC class II… CONTINUE READING
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