Antigen specific suppressor T cells from chronic hepatitis B virus (HBV) carriers inhibit the responsiveness to HBsAg of allogeneic high-responder lymphocytes.

@article{Barnaba1985AntigenSS,
  title={Antigen specific suppressor T cells from chronic hepatitis B virus (HBV) carriers inhibit the responsiveness to HBsAg of allogeneic high-responder lymphocytes.},
  author={Vincenzo Barnaba and Massimo Levrero and Alessandra Franco and C Zaccari and Antonino Musca and Francesco Balsano},
  journal={Journal of clinical & laboratory immunology},
  year={1985},
  volume={16 3},
  pages={137-42}
}
Immunoregulatory mechanisms in chronic HBsAg carriers have been investigated through the study of in vitro proliferative responses to HBsAg by allogeneic coculture experiments between T lymphocytes from HBsAg + chronic active hepatitis (CAH) patients (HBsAg no responder) and PBMC from subjects boosted with anti-hepatitis B vaccine (high responder). When high-responder PBMC have been challenged with the hepatitis B surface antigen (HBsAg) in the presence of HBsAg no-responder T lymphocytes… CONTINUE READING