Antigen-specific suppressive factor produced by a transplantable I-J bearing T-cell hybridoma

@article{Taniguchi1979AntigenspecificSF,
  title={Antigen-specific suppressive factor produced by a transplantable I-J bearing T-cell hybridoma},
  author={Masaru Taniguchi and Takashi K. Saito and Tomio Tada},
  journal={Nature},
  year={1979},
  volume={278},
  pages={555-558}
}
THE demonstration of a definite antigen-binding specificity possessed by suppressor T cells and suppressor factors1–6 has provided an important strategy to determine the T-cell receptor for antigen. Although the gene coding for the determinant on the suppressor molecule has been unambiguously mapped in the I–J subregion of the mouse major histocompatibility complex (MHC)3,7, the chemistry and the mode of action of the active molecule have been only poorly analysed—probably because of the… CONTINUE READING