Antigen-specific peripheral tolerance induced by topical application of NF-kappaB decoy oligodeoxynucleotide.

@article{Isomura2006AntigenspecificPT,
  title={Antigen-specific peripheral tolerance induced by topical application of NF-kappaB decoy oligodeoxynucleotide.},
  author={Iwao Isomura and Kunio Tsujimura and Akimichi Morita},
  journal={The Journal of investigative dermatology},
  year={2006},
  volume={126 1},
  pages={
          97-104
        }
}
Activation and maturation of dendritic cells (DC) are crucial for the establishment of delayed-type hypersensitivity (DTH). However, antigen presentation by immature DC (iDC) might lead to antigen-specific peripheral tolerance. NF-kappaB plays significant roles in upregulation of co-stimulatory molecules and cytokines in DC and therefore we investigated whether NF-kappaB decoy oligodeoxynucleotide (ODN) might induce tolerance to DTH. NF-kappaB decoy ODN suppressed ovalbumin (OVA)-induced DTH… CONTINUE READING
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