Antigen-specific peripheral immune responses are unaltered during normal pregnancy in sheep.

@article{Wattegedera2008AntigenspecificPI,
  title={Antigen-specific peripheral immune responses are unaltered during normal pregnancy in sheep.},
  author={Sean R Wattegedera and Mara Rocchi and Jill Sales and Christopher J Howard and Jayne C Hope and Gary Entrican},
  journal={Journal of reproductive immunology},
  year={2008},
  volume={77 2},
  pages={171-8}
}
A shift in the balance of T(Helper) (T(H))1/T(H)2 cytokine production by maternal peripheral blood leukocytes is regarded as a common important feature of successful mammalian pregnancy. Although the phenomenon has been studied extensively in animals with invasive hemochorial placentae, the paradigm has not been studied in detail in species with less-invasive placentae, such as sheep that have a synepitheliochorial placenta. Sixteen sheep were immunised with the nominal antigen chicken egg… CONTINUE READING