Antigen-specific memory B cell development.

  title={Antigen-specific memory B cell development.},
  author={Louise J. McHeyzer-Williams and Michael G. McHeyzer-Williams},
  journal={Annual review of immunology},
Helper T (Th) cell-regulated B cell immunity progresses in an ordered cascade of cellular development that culminates in the production of antigen-specific memory B cells. The recognition of peptide MHC class II complexes on activated antigen-presenting cells is critical for effective Th cell selection, clonal expansion, and effector Th cell function development (Phase I). Cognate effector Th cell-B cell interactions then promote the development of either short-lived plasma cells (PCs) or… CONTINUE READING
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