Antigen-specific lymphocytes enhance nitric oxide production in Mycobacterium bovis BCG-infected bovine macrophages.

@article{Carpenter1998AntigenspecificLE,
  title={Antigen-specific lymphocytes enhance nitric oxide production in Mycobacterium bovis BCG-infected bovine macrophages.},
  author={Elizabeth A Carpenter and Linley M Fray and Eamonn Gormley},
  journal={Immunology and cell biology},
  year={1998},
  volume={76 4},
  pages={
          363-8
        }
}
Nitric oxide (NO) production was evaluated in macrophages isolated from Mycobacterium bovis bacille Calmette-Guérin (BCG)-immunized, and control non-immunized, cattle. Incubation of M. bovis BCG-infected macrophages with recombinant bovine IFN-gamma led to increased nitrite levels in culture supernatants. It was also demonstrated that NO production by autologous M. bovis BCG-infected macrophages increased in a linear relationship with the number of antigen-specific lymphocytes added to cultures… CONTINUE READING

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