Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis).

@article{Satoguina2002AntigenspecificTR,
  title={Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis).},
  author={Judith Satoguina and Martin Mempel and John Aseidu Larbi and Marlis Badusche and Cornelius Loeliger and Ohene Adjei and Gabriel Gachelin and Bernhard Fleischer and Achim Hoerauf},
  journal={Microbes and infection},
  year={2002},
  volume={4 13},
  pages={1291-300}
}
Different mechanisms underlie the phenomenon of peripheral tolerance. Recently, a new subset of CD4+ T cells, called T regulatory-1 (Tr1) cells, was described which show suppressor functions in vitro and in vivo and are characterized by a predominant production of IL-10 and/or TGF-beta. Tr1 cells have so far been generated experimentally in an IL-10-rich environment and hold promise for exploitation in the suppression of alloreactions and inflammatory or allergic dispositions. However, these… CONTINUE READING