Antigen-specific T-lymphocyte function after cord blood transplantation.

@article{Cohen2006AntigenspecificTF,
  title={Antigen-specific T-lymphocyte function after cord blood transplantation.},
  author={Geoff R Cohen and Shelly L Carter and Kenneth I. Weinberg and Bernadette Masinsin and Eva C. Guinan and Joanne Kurtzberg and John E Wagner and Nancy A Kernan and Robertson Parkman},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2006},
  volume={12 12},
  pages={1335-42}
}
It has not been possible to determine the singular contribution of naive T lymphocytes to antigen-specific immunity after hematopoietic stem cell transplantation (HSCT), because of the confounding effects of donor-derived antigen-specific T lymphocytes present in most hematopoietic stem cell (HSC) products. Because umbilical cord blood contains only naive T lymphocytes, we longitudinally evaluated the recipients of unrelated cord blood transplantation (UCBT) for the presence of T lymphocytes… CONTINUE READING
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