Antigen-specific T-cell lines transfer protective immunity against Trichinella spiralis in vivo.

Abstract

T-cell lines specific for infective muscle larvae antigens of the intestinal nematode Trichinella spiralis have been generated in vitro. These antigen-specific T-cell lines express the L3T4+ Ly2- phenotype and secrete the lymphokines IL-2, IL-3 and gamma-IFN. They are stable in culture for up to 15 weeks and are protective when adoptively transferred into naive recipients. As few as 2 x 10(5) T. spiralis-specific tract. In addition, intestinal mastocytosis and peripheral blood eosinophilia were accelerated after adoptive transfer of T. spiralis-specific T-cell lines.

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@article{Riedlinger1986AntigenspecificTL, title={Antigen-specific T-cell lines transfer protective immunity against Trichinella spiralis in vivo.}, author={Julia Riedlinger and Richard K Grencis and Derek R. Wakelin}, journal={Immunology}, year={1986}, volume={58 1}, pages={57-61} }