Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine.

@article{Horowitz2012AntigenspecificIS,
  title={Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine.},
  author={Amir Horowitz and Julius C. R. Hafalla and Elizabeth Camp King and John Lusingu and Denise Andrea Dekker and Amanda R. Leach and Philippe J. Moris and Joe Cohen and J. Vekemans and Tonya Villafana and Patrick H. Corran and Philip Bejon and Christopher J. Drakeley and Lorenz von Seidlein and Eleanor M. Riley},
  journal={Journal of immunology},
  year={2012},
  volume={188 10},
  pages={
          5054-62
        }
}
RTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum, is undergoing clinical trials. We report an analysis of cellular immune response to component Ags of RTS,S-hepatitis B surface Ag (HBs) and P. falciparum circumsporozoite (CS) protein-among Tanzanian children in a phase IIb RTS,S/AS01(E) trial. RTS,S/AS01 (E) vaccinees make stronger T cell IFN-γ, CD69, and CD25 responses to HBs peptides than do controls, indicating that RTS,S boosts pre-existing HBs responses. T… CONTINUE READING
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RTS,S Vaccine Evaluation Group

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