Antigen-specific CD4+ T cells recognize epitopes of protective antigen following vaccination with an anthrax vaccine.

@article{Laughlin2007AntigenspecificCT,
  title={Antigen-specific CD4+ T cells recognize epitopes of protective antigen following vaccination with an anthrax vaccine.},
  author={Elsa M. Laughlin and Joseph I. Miller and Eddie James and Dimitri Fillos and Chris C. Ibegbu and Robert S. Mittler and Rama S Akondy and William W Kwok and Rafi Ahmed and Gerald T Nepom},
  journal={Infection and immunity},
  year={2007},
  volume={75 4},
  pages={
          1852-60
        }
}
Detection of antigen-specific CD4+ T cells is facilitated by the use of fluorescently labeled soluble peptide-major histocompatibility complex (MHC) multimers which mirror the antigen specificity of T-cell receptor recognition. We have used soluble peptide-MHC class II tetramers containing peptides from the protective antigen (PA) of Bacillus anthracis to detect circulating T cells in peripheral blood of subjects vaccinated with an anthrax vaccine. PA-specific HLA class II-restricted T… CONTINUE READING

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