Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling.

@article{Nagaraj2012AntigenspecificCT,
  title={Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling.},
  author={Srinivas Ghante Nagaraj and Allison Nelson and Je-in Youn and Pingyan Cheng and David G. Quiceno and Dmitry I Gabrilovich},
  journal={Cancer research},
  year={2012},
  volume={72 4},
  pages={928-38}
}
Myeloid-derived suppressor cells (MDSC) play a major role in cancer-related immune suppression, yet the nature of this suppression remains controversial. In this study, we evaluated the ability of MDSCs to elicit CD4(+) T-cell tolerance in different mouse tumor models. In contrast to CD8(+) T-cell tolerance, which could be induced by MDSCs in all the tumor models tested, CD4(+) T-cell tolerance could be elicited in only one of the models (MC38) in which a substantial level of MHC class II was… CONTINUE READING
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