Antigen-specific B cells present cartilage proteoglycan (aggrecan) to an autoreactive T cell hybridoma derived from a mouse with proteoglycan-induced arthritis.

@article{Brennan1995AntigenspecificBC,
  title={Antigen-specific B cells present cartilage proteoglycan (aggrecan) to an autoreactive T cell hybridoma derived from a mouse with proteoglycan-induced arthritis.},
  author={Frank R. Brennan and Katalin Mikecz and Edit Ir{\'e}n Buz{\'a}s and D R Ragasa and Gabriella Cs-Szab{\'o} and Gabriela Negroiu and Tibor T. Glant},
  journal={Clinical and experimental immunology},
  year={1995},
  volume={101 3},
  pages={414-21}
}
Cartilage proteoglycan (aggrecan)-induced polyarthritis in BALB/c mice is characterized by chronic inflammation and destruction of joint tissues similar to that observed in human rheumatoid arthritis. The immunization of mice with fetal human proteoglycan (PG) elicits specific antibodies to the immunizing antigen of which a population cross-reacts with native mouse PG. This (auto)antibody production is immediately followed by an explosive proliferation of autoreactive T cells, suggesting that… CONTINUE READING

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