Antigen-selected T-cell receptor diversity and self-nonself homology.


Recent studies indicate that the T-cell receptor (TCR) repertoire selected by certain antigenic peptide-MHC combinations can be extremely diverse. This is in contrast to earlier studies reporting T-cell responses which were limited in terms of TCR diversity. In this viewpoint, we suggest these variations in TCR diversity may be explained by taking into… (More)


Cite this paper

@article{Casanova1993AntigenselectedTR, title={Antigen-selected T-cell receptor diversity and self-nonself homology.}, author={J. L. Casanova and Janet L. Maryanski}, journal={Immunology today}, year={1993}, volume={14 8}, pages={391-4} }