Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria

@inproceedings{Ros2016AntigenSB,
  title={Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria},
  author={Daniel Zavala R{\'i}os and Megan B. Wood and Jian-Dong Li and Benoit Chassaing and Andrew T. Gewirtz and Ifor R Williams},
  booktitle={Mucosal Immunology},
  year={2016}
}
Secretory IgA (SIgA) directed against gut resident bacteria enables the mammalian mucosal immune system to establish homeostasis with the commensal gut microbiota after weaning. Germinal centers (GCs) in Peyer’s patches (PPs) are the principal inductive sites where naive B cells specific for bacterial antigens encounter their cognate antigens and receive T-cell help driving their differentiation into IgA-producing plasma cells. We investigated the role of antigen sampling by intestinal M cells… CONTINUE READING
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