Antigen receptor signaling: integration of protein tyrosine kinase functions

@article{Tamir1998AntigenRS,
  title={Antigen receptor signaling: integration of protein tyrosine kinase functions},
  author={Idan Tamir and John C Cambier},
  journal={Oncogene},
  year={1998},
  volume={17},
  pages={1353-1364}
}
Antigen receptors on T and B cells function to transduce signals leading to a variety of biologic responses minimally including antigen receptor editing, apoptotic death, developmental progression, cell activation, proliferation and survival. The response to antigen depends upon antigen affinity and valence, involvement of coreceptors in signaling and differentiative stage of the responding cell. The requirement that these receptors integrate signals that drive an array of responses may explain… CONTINUE READING