Antigen receptor proximal signaling in splenic B-2 cell subsets.

  title={Antigen receptor proximal signaling in splenic B-2 cell subsets.},
  author={Xiaohua Li and Flavius Martin and Alyce M. Oliver and John F Kearney and Robert H. Carter},
  journal={Journal of immunology},
  volume={166 5},
Splenic marginal zone (MZ) and follicular mantle (FO) B cells differ in their responses to stimuli in vitro and in vivo. We have previously shown that MZ cells exhibit greater calcium responses after ligation of membrane IgM (mIgM). We have now investigated the molecular mechanism underlying the difference in calcium responses following ligation of mIgM and studied the response to total B cell receptor ligation in these two subsets. We compared key cellular proteins involved in calcium… CONTINUE READING


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