Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases.

@article{Taniuchi1995AntigenreceptorIC,
  title={Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases.},
  author={Ichiro Taniuchi and Daisuke Kitamura and Yoichi Maekawa and Takahiro Fukuda and Hiroyuki Kishi and Toshiyuki Watanabe},
  journal={The EMBO journal},
  year={1995},
  volume={14 15},
  pages={3664-78}
}
HS1, an intracellular protein expressed specifically in hematopoietic cells, is rapidly tyrosine phosphorylated after cross-linking of antigen receptors on B and T lymphocytes, implicating involvement of this molecule in the signal transduction pathways from the antigen receptors as a substrate of membrane-associated tyrosine kinase(s). The development of lymphoid cells in HS1-deficient mice, generated through gene targeting, appeared normal. However, antibody production to T-independent… CONTINUE READING

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