Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice

  title={Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice},
  author={F. Nagawa and Natsuko Kishishita and K. Shimizu and S. Hirose and M. Miyoshi and J. Nezu and T. Nishimura and H. Nishizumi and Y. Takahashi and S. Hashimoto and M. Takeuchi and A. Miyajima and T. Takemori and A. J. Otsuka and H. Sakano},
  journal={Nature Immunology},
  • F. Nagawa, Natsuko Kishishita, +12 authors H. Sakano
  • Published 2007
  • Biology, Medicine
  • Nature Immunology
  • Jawless vertebrates have acquired immunity but do not have immunoglobulin-type antigen receptors. Variable lymphocyte receptors (VLRs) have been identified in lamprey that consist of multiple leucine-rich repeat (LRR) modules. An active VLR gene is generated by the assembly of a series of variable gene segments, including many that encode LRRs. Stepwise assembly of the gene segments seems to occur by replacement of the intervening DNA between the 5′ and 3′ constant-region genes. Here we report… CONTINUE READING
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