Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice

@article{Nagawa2007AntigenreceptorGO,
  title={Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice},
  author={Fumikiyo Nagawa and Natsuko Kishishita and Kazumichi Shimizu and Satoshi Hirose and Masato Miyoshi and J i Nezu and Toshinobu Nishimura and Hirofumi Nishizumi and Yoshimasa Takahashi and Shu-ichi Hashimoto and Masaki Takeuchi and Atsushi Miyajima and Toshitada Takemori and Anthony J. Otsuka and Hitoshi Sakano},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={206-213}
}
Jawless vertebrates have acquired immunity but do not have immunoglobulin-type antigen receptors. Variable lymphocyte receptors (VLRs) have been identified in lamprey that consist of multiple leucine-rich repeat (LRR) modules. An active VLR gene is generated by the assembly of a series of variable gene segments, including many that encode LRRs. Stepwise assembly of the gene segments seems to occur by replacement of the intervening DNA between the 5′ and 3′ constant-region genes. Here we report… Expand
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