Antigen receptor engagement selectively induces macrophage inflammatory protein-1 alpha (MIP-1 alpha) and MIP-1 beta chemokine production in human B cells.

@article{Krzysiek1999AntigenRE,
  title={Antigen receptor engagement selectively induces macrophage inflammatory protein-1 alpha (MIP-1 alpha) and MIP-1 beta chemokine production in human B cells.},
  author={Roman Krzysiek and Eric A. Lefevre and Weiping Zou and Arnaud Foussat and J{\'e}r{\^o}me Bernard and Alain Portier and Pierre Galanaud and Yolande Richard},
  journal={Journal of immunology},
  year={1999},
  volume={162 8},
  pages={4455-63}
}
We show herein that B cell Ag receptor (BCR) triggering, but not stimulation by CD40 mAb and/or IL-4, rapidly induced the coordinated expression of two closely related T cell chemoattractants, macrophage inflammatory protein-1 beta (MIP-1 beta) and MIP-1 alpha, by human B cells. Naive, memory, and germinal center B cells all produced MIP-1 alpha/beta in response to BCR triggering. In contrast to MIP-1 alpha/beta, IL-8, which is spontaneously produced by germinal center B cells but not by naive… CONTINUE READING

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