Antigen-receptor complex stimulation triggers protein kinase C- dependent CD11a/CD18-cytoskeleton association in T lymphocytes

@article{Pardi1992AntigenreceptorCS,
  title={Antigen-receptor complex stimulation triggers protein kinase C- dependent CD11a/CD18-cytoskeleton association in T lymphocytes},
  author={Ruggero Pardi and Luca Alessandro Inverardi and Claudio Rugarli and Jeffrey R Bender},
  journal={The Journal of Cell Biology},
  year={1992},
  volume={116},
  pages={1211 - 1220}
}
Although it is well accepted that intercellular adhesion involving the CD11a/CD18 (LFA-1) complex is critical in a wide array of T cell-dependent processes, recent demonstrations of an LFA-1 high avidity state, induced by triggering the T cell receptor (TCR) complex, has raised questions about the intracellular signals generated and molecular events leading to effective cell coupling, as well as their orderly sequence. In this study, we assessed the effects of T cell activation on the actin… CONTINUE READING

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