Antigen receptor allelic exclusion: an update and reappraisal.

@article{Brady2010AntigenRA,
  title={Antigen receptor allelic exclusion: an update and reappraisal.},
  author={Brenna L. Brady and Natalie C. Steinel and Craig H. Bassing},
  journal={Journal of immunology},
  year={2010},
  volume={185 7},
  pages={
          3801-8
        }
}
Most lymphocytes express cell surface Ag receptor chains from single alleles of distinct Ig or TCR loci. Since the identification of Ag receptor allelic exclusion, the importance of this process and the precise molecular mechanisms by which it is achieved have remained enigmatic. This brief review summarizes current knowledge of the extent to which Ig and TCR loci are subject to allelic exclusion. Recent progress in studying and defining mechanistic steps and molecules that may control the… CONTINUE READING

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