Antigen processing by the proteasome.

  title={Antigen processing by the proteasome.},
  author={Peter Michael Kloetzel},
  journal={Nature reviews. Molecular cell biology},
  volume={2 3},
The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes--the waste-disposal units of the cell--typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well? 
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