Antigen processing and presentation of a naturally glycosylated protein elicits major histocompatibility complex class II-restricted, carbohydrate-specific T cells.

@article{Michalsson1996AntigenPA,
  title={Antigen processing and presentation of a naturally glycosylated protein elicits major histocompatibility complex class II-restricted, carbohydrate-specific T cells.},
  author={E Micha{\"e}lsson and Johan Broddefalk and Ake Engstr{\"o}m and Jan Kihlberg and Rikard Holmdahl},
  journal={European journal of immunology},
  year={1996},
  volume={26 8},
  pages={
          1906-10
        }
}
It is well known that T cells recognize antigen as processed peptides bound to major histocompatibility complex molecules on the surface of antigen-presenting cells. Recently, it has been shown that T cells can specifically recognize synthetic glycopeptides. However, whether glycopeptides are selected for presentation during antigen processing of glycoproteins and eventually elicit carbohydrate-specific T cells is still an open question. In this study, we utilized synthetic glycopeptides to… CONTINUE READING

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