Antigen processing: HLA-DO –  a hitchhiking inhibitor of HLA-DM

@article{Jensen1998AntigenPH,
  title={Antigen processing: HLA-DO –  a hitchhiking inhibitor of HLA-DM},
  author={Peter Egede Jensen},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={R128-R131}
}
Recent studies have revealed that the conserved major histocompatibility complex class II molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed peptide loading of class II molecules.