Antigen-presenting function of mouse CD1: one molecule with two different kinds of antigenic ligands.

@article{Brossay1998AntigenpresentingFO,
  title={Antigen-presenting function of mouse CD1: one molecule with two different kinds of antigenic ligands.},
  author={Laurent Brossay and Nicolas Burdin and Sandra S Tangri and Mitchell Kronenberg},
  journal={Immunological reviews},
  year={1998},
  volume={163},
  pages={139-50}
}
Mouse CD1 (mCD1) is an antigen-presenting molecule that is constitutively expressed by most bone marrow-derived cells. Peptides with a hydrophobic binding motif can bind to mCD1, and the peptide-CD1 complex is recognized by CD8+ cytolytic T cells. In contrast, NK1.1+ T cells, which are CD8-, are autoreactive for mCD1 molecules. This autoreactivity, along with the ability of NK T cells to rapidly produce large amounts of cytokine, has led to the suggestion that these cells may be… CONTINUE READING

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