• Biology, Medicine
  • Published in Journal of immunology 1994

Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells.

@article{Epperson1994AntigenpresentingFO,
  title={Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells.},
  author={Diane E. Epperson and Jordan S Pober},
  journal={Journal of immunology},
  year={1994},
  volume={153 12},
  pages={
          5402-12
        }
}
We characterized the response of resting human CD8 T cells to allogeneic endothelial cells (EC). Both resting and IFN-gamma-pretreated EC stimulate similar CD8 T cell proliferative responses (peak, day 5 to 6), whereas only IFN-gamma-pretreated EC stimulate CD4 T cells. The response increases with increasing numbers of CD8 T cells from 25,000 to 400,000/well. The proliferation of CD8 T cells is inhibited by mAbs reactive with CD8 or HLA-A and -B molecules but not with CD4 or HLA-DR. mAb… CONTINUE READING

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