Antigen presenting cell-derived IL-6 restricts Th2-cell differentiation.

  title={Antigen presenting cell-derived IL-6 restricts Th2-cell differentiation.},
  author={Alice Mayer and Delphine Debuisson and S{\'e}bastien Denanglaire and Fouad Eddahri and Laurence Fi{\'e}vez and M{\'e}lanie Hercor and Emily Triffaux and M. G. Moser and Fabrice Bureau and Oberdan Leo and Fabienne Andris},
  journal={European journal of immunology},
  volume={44 11},
The identification of DC-derived signals orchestrating activation of Th1 and Th17 immune responses has advanced our understanding on how these inflammatory responses develop. However, whether specific signals delivered by DCs also participate in the regulation of Th2 immune responses remains largely unknown. In this study, we show that administration of antigen-loaded, IL-6-deficient DCs to naïve mice induced an exacerbated Th2 response, characterized by the differentiation of GATA-3-expressing… CONTINUE READING
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