Antigen-presenting B cells and helper T cells cooperatively mediate intravirionic antigenic competition between influenza A virus surface glycoproteins.

@article{Johansson1987AntigenpresentingBC,
  title={Antigen-presenting B cells and helper T cells cooperatively mediate intravirionic antigenic competition between influenza A virus surface glycoproteins.},
  author={Bert E. Johansson and Thomas M. Moran and Edwin D. Kilbourne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 19},
  pages={6869-73}
}
Parenteral vaccination of BALB/c mice primed by infection with H3N2 variants of influenza A virus results in a reduced production of N2 antibody in response to homologous (H3N2) vaccine compared with the response to an H7N2 vaccine equal in N2 immunologenicity. We now have studied the interaction in vitro of purified splenic B and T lymphocytes from variably immunized mice to ascertain the cellular basis of the hemagglutinin (HA)-influenced antibody response to neuraminidase (NA). Assay of the… CONTINUE READING

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[Influenza viruses and influenza vaccines (author's transl)].

Therapeutische Umschau. Revue therapeutique • 1974

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