Antigen presentation in retroviral vector-mediated gene transfer in vivo.

  title={Antigen presentation in retroviral vector-mediated gene transfer in vivo.},
  author={Eun Sook Song and Vivian Wai Han Lee and Charles D. Surh and Aenoch J. Lynn and D Brumm and Douglas J Jolly and John F. Warner and Sunil Chada},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 5},
We have examined mechanisms involved in gene transfer, protein expression, and antigen presentation after direct administration of retroviral vectors using a variety of antigen systems. We have identified transduced infiltrating cells at the injection site, and the majority of the infiltrating cells were of the monocyte/macrophage lineage. We found that the splenic dendritic cell fraction contained proviral DNA, expressed antigenic proteins, and was able to present antigens efficiently to the… CONTINUE READING


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