Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

@article{Peterson1992AntigenPE,
  title={Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41},
  author={Mary Peterson and Jim Miller},
  journal={Nature},
  year={1992},
  volume={357},
  pages={596-598}
}
DURING biosynthesis, class II molecules of the major histo-compatibility complex are associated with a nonpolymorphic protein called invariant chain, li, which facilitates folding of class II molecules and their exit from the endoplasmic reticulum1–4, interferes with their association with peptide5,6 and directs their post-Golgi transport (refs 7–9). If li blocks class II loading with endogenous antigens in the endoplasmic reticulum and/or directs class II molecules to the exogenous antigen… CONTINUE READING

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