Corpus ID: 19311878

Antigen presentation by dendritic cells focuses T cell responses against immunodominant peptides: studies in the hen egg-white lysozyme (HEL) model.

@article{Gapin1998AntigenPB,
  title={Antigen presentation by dendritic cells focuses T cell responses against immunodominant peptides: studies in the hen egg-white lysozyme (HEL) model.},
  author={L. Gapin and Y. Bravo de Alba and A. Casrouge and J. P. Cabaniols and P. Kourilsky and J. Kanellopoulos},
  journal={Journal of immunology},
  year={1998},
  volume={160 4},
  pages={
          1555-64
        }
}
  • L. Gapin, Y. Bravo de Alba, +3 authors J. Kanellopoulos
  • Published 1998
  • Medicine, Biology
  • Journal of immunology
  • T lymphocyte responses to a protein Ag are restricted to a limited number of determinants and not to all peptides capable of binding to MHC class II molecules. This focusing of the immune response is defined as immunodominance and has been observed with numerous protein Ags. In the H-2d haplotype, hen egg-white lysozyme (HEL)-specific T lymphocytes react with I-Ed-restricted peptides derived from a single immunodominant (ID) region (HEL 103-117). Moreover, we have recently found that another… CONTINUE READING
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