Antigen presentation by dendritic cells and their significance in antineoplastic immunotherapy.

@article{Bodey2004AntigenPB,
  title={Antigen presentation by dendritic cells and their significance in antineoplastic immunotherapy.},
  author={Bela Bodey and Stuart E. Siegel and Hans E. Kaiser},
  journal={In vivo},
  year={2004},
  volume={18 1},
  pages={81-100}
}
Dendritic cells (DCs) are present in essentially every mammalian tissue, where they operate at the interface of innate and acquired immunity by recognizing pathogens and presenting pathogen-derived peptides to T lymphocytes. According to the research group of Shortman, experimental results suggest a "dual" DC differentiation model, demonstrating the existence of both myeloid-derived (with characteristic IF: CD11b+, CD11c+, CD8alpha- and DEC205+) and lymphoid-derived DCs (showing CD11b- CD11c… CONTINUE READING