Antigen presentation by a continuous human microvascular endothelial cell line, HMEC-1, to human T cells.

@article{Bosse1993AntigenPB,
  title={Antigen presentation by a continuous human microvascular endothelial cell line, HMEC-1, to human T cells.},
  author={Diane C. Bosse and Velma G. George and Francisco J. Candal and T. J. Lawley and Edwin W. Ades},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  year={1993},
  volume={61 3-4},
  pages={236-8}
}
Endothelial cells line the vessels and lymphatics of the body, acting as a barrier between the blood and extravascular tissue. These cells are, therefore, in a prime position to play a role in lymphocyte activation. Indeed, it has been shown that primary endothelial cells in culture are capable of presenting particulate and soluble antigens to T cells and that this response is not dependent on macrophages. Recently, we developed an immortalized line of human microvascular endothelial cells, CDC… CONTINUE READING