Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice.

@article{Faveeuw2002AntigenPB,
  title={Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice.},
  author={Christelle Faveeuw and Veronique Angeli and Josette Fontaine and Charles R. Maliszewski and Andr{\'e} Capron and Luc Van Kaer and M. G. Moser and Monique Capron and François Trottein},
  journal={Journal of immunology},
  year={2002},
  volume={169 2},
  pages={906-12}
}
During murine schistosomiasis, there is a gradual switch from a predominant Th1 cytokine response to a Th2-dominated response after egg laying, an event that favors the formation of granuloma around viable eggs. Egg-derived glycoconjugates, including glycolipids, may play a crucial role in this phenomenon. In this study, we used a model of dendritic cell sensitization to study the role of egg glycoconjugates in the induction of specific immune response to soluble egg Ag (SEA) and to investigate… CONTINUE READING
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