Antigen presentation and cytotoxic T lymphocyte killing studied in individual, living cells.

@article{Hahn1994AntigenPA,
  title={Antigen presentation and cytotoxic T lymphocyte killing studied in individual, living cells.},
  author={Klaus Michael Hahn and Robbin L. Debiasio and Antoinette Tishon and Hanna A. Lewicki and Jean Edouard Gairin and Gina M Larocca and Dorothy L. Taylor and Michael B A Oldstone},
  journal={Virology},
  year={1994},
  volume={201 2},
  pages={
          330-40
        }
}
Interactions between individual, living fibroblasts and cytotoxic T lymphocyte (CTL) clones were analyzed by using video-enhanced differential interference contrast and fluorescence microscopy in a multimode configuration. Fibroblasts expressing known major histocompatibility complex I alleles (MC57: H-2b; Balb: H-2d) were sensitized for killing by incubating or microinjecting them with peptide fragments of lymphocytic choriomeningitis virus. Previous determination of the CTL clones… CONTINUE READING
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