Antigen microarray profiling of autoantibodies in rheumatoid arthritis.

@article{Hueber2005AntigenMP,
  title={Antigen microarray profiling of autoantibodies in rheumatoid arthritis.},
  author={Wolfgang Hueber and Brian A. Kidd and Beren H. Tomooka and Byung Jae Lee and Bonnie B Bruce and James F. Fries and Grete S{\o}nderstrup and Paul Monach and Jan Wouter Drijfhout and Walther J. van Venrooij and Paul Joseph Utz and Mark C Genovese and William H Robinson},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 9},
  pages={
          2645-55
        }
}
OBJECTIVE Because rheumatoid arthritis (RA) is a heterogeneous autoimmune disease in terms of disease manifestations, clinical outcomes, and therapeutic responses, we developed and applied a novel antigen microarray technology to identify distinct serum antibody profiles in patients with RA. METHODS Synovial proteome microarrays, containing 225 peptides and proteins that represent candidate and control antigens, were developed. These arrays were used to profile autoantibodies in randomly… CONTINUE READING
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