Antigen loading of MHC class I molecules in the endocytic tract.

  title={Antigen loading of MHC class I molecules in the endocytic tract.},
  author={Monique J. Kleijmeer and Jean Michel Escola and Fons G Uytdehaag and Eva Jakobson and Janice M. Griffith and Albert D. M. E. Osterhaus and Willem Stoorvogel and Cornelis J M Melief and Catherine Rabouille and Hans J. Geuze},
  volume={2 2},
Major histocompatibility complex (MHC) class I molecules bind antigenic peptides that are translocated from the cytosol into the endoplasmic reticulum by the transporter associated with antigen processing. MHC class I loading independent of this transporter also exists and involves peptides derived from exogenously acquired antigens. Thus far, a detailed characterization of the intracellular compartments involved in this pathway is lacking. In the present study, we have used the model system in… CONTINUE READING
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MHC class II compartments represent conventional endocytic compartments in human and mouse B lymphoblasts

  • MJ Kleijmeer, S Morkowsky, J Griffith, AY Rudensky, HJ. Geuze
  • J Cell Biol
  • 1997
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