• Biology, Medicine
  • Published in Immunology 1975

Antigen-initiated B-lymphocyte differentiation. VII. Quantification of AFC progenitor levels in adoptive and culture responses to NIP-POL antigen.

@article{Schlegel1975AntigeninitiatedBD,
  title={Antigen-initiated B-lymphocyte differentiation. VII. Quantification of AFC progenitor levels in adoptive and culture responses to NIP-POL antigen.},
  author={Robert A. Schlegel and John M. Fidler and Mary Howard and Ken Shortman},
  journal={Immunology},
  year={1975},
  volume={29 6},
  pages={
          1029-40
        }
}
Quantitative studies on B cells require a direct assay for antibody-forming cell (AFC) progenitor function, in which the number of AFC produced bears a simple, linear arithmetic relationship to the number of progenitors present. This might be expected under conditions where helper T-cell and accessory cell requirements are by-passed, or provided in excess. This possibility has been tested using as antigen the hapten NIP (4-hydroxy-3-iodo-5-nitrophenylacetic acid) on the carrier POL (polymerized… CONTINUE READING