Antigen-induced regulatory T cells in autoimmunity.

  title={Antigen-induced regulatory T cells in autoimmunity.},
  author={Matthias G von Herrath and Leonard C. Harrison},
  journal={Nature reviews. Immunology},
  volume={3 3},
The ultimate goal of any treatment for autoimmune diseases is antigen- and/or site-specific suppression of pathology. Autoaggressive lymphocytes need to be eliminated or controlled to prevent tissue damage and halt the progression of clinical disease. Strong evidence is emerging that the induction of regulatory T (T(Reg)) cells by autoantigens can suppress disease, even if the primary, initiating autoantigens are unknown and if inflammation is progressive. An advantage of these autoreactive T… CONTINUE READING

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