Antigen engineering can play a critical role in the protective immunity elicited by Yersinia pestis DNA vaccines.

@article{Wang2010AntigenEC,
  title={Antigen engineering can play a critical role in the protective immunity elicited by Yersinia pestis DNA vaccines.},
  author={Shixia Wang and Innocent Mboudjeka and Jon D Goguen and Shan Lu},
  journal={Vaccine},
  year={2010},
  volume={28 8},
  pages={2011-9}
}
The use of a DNA immunization approach to deliver protective antigens against Yersinia pestis (Y. pestis) has been successful in previously reported studies. In the current study, the gene designs for V and F1, two well-studied virulent factors serving as main targets for vaccine development, were altered to explore additional options in hopes of improving the protective immunity of DNA vaccines expressing these two antigens. Compared to the wild type V gene DNA vaccines, the use of codon… CONTINUE READING
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