Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection.

@article{Miles2011AntigendrivenPO,
  title={Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection.},
  author={John J. Miles and Duangtawan Thammanichanond and Sarah Moneer and Usha K. Nivarthi and Lars Kjer-Nielsen and Samantha Lilly Tracy and Campbell Kynoch Aitken and Rebekah M. Brennan and Weiguang Zeng and Louise Marquart and David T. Jackson and Jacqueline M. Burrows and David Bowden and Joseph Torresi and Margaret Hellard and Jamie Rossjohn and James McCluskey and Mandvi Bharadwaj},
  journal={Journal of immunology},
  year={2011},
  volume={186 2},
  pages={
          901-12
        }
}
Hepatitis C virus (HCV) infection causes significant morbidity and mortality worldwide. T cells play a central role in HCV clearance; however, there is currently little understanding of whether the disease outcome in HCV infection is influenced by the choice of TCR repertoire. TCR repertoires used against two immunodominant HCV determinants--the highly polymorphic, HLA-B*0801 restricted (1395)HSKKKCDEL(1403) (HSK) and the comparatively conserved, HLA-A*0101-restricted, (1435)ATDALMTGY(1443… CONTINUE READING
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