Antigen-driven focal inflammatory death of malaria liver stages

  title={Antigen-driven focal inflammatory death of malaria liver stages},
  author={Ganchimeg Bayarsaikhan and Masoud Akbari and Katsuyuki Yui and Rogerio Amino},
  booktitle={Front. Microbiol.},
Multiple immunizations using live irradiated sporozoites, the infectious plasmodial stage delivered into the host skin during a mosquito bite, can elicit sterile immunity to malaria. CD8(+) T cells seem to play an essential role in this protective immunity, since their depletion consistently abolishes sterilizing protection in several experimental models. So far, only a few parasite antigens are known to induce CD8(+) T cell-dependent protection, but none of them can reach the levels of… CONTINUE READING
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