Antigen-driven effector CD8 T cell function regulated by T-bet.

@article{Sullivan2003AntigendrivenEC,
  title={Antigen-driven effector CD8 T cell function regulated by T-bet.},
  author={Brandon M. Sullivan and Amy E. Juedes and Susanne J. Szabo and L. H. Glimcher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 26},
  pages={
          15818-23
        }
}
Type 1 immunity relies on the differentiation of two major subsets of T lymphocytes, the CD4+ T helper (Th) cell and the CD8+ cytotoxic T cell, that direct inflammatory and cytotoxic responses essential for the destruction of intracellular and extracellular pathogens. In contrast to CD4 cells, little is known about transcription factors that control the transition from the CD8 naïve to effector cell stage. Here, we report that the transcription factor T-bet, known to regulate Th cell… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 182 CITATIONS, ESTIMATED 42% COVERAGE

464 Citations

0204060'06'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 464 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…