Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes

@article{Krause1998AntigendependentCS,
  title={Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes },
  author={Andrea Monsalve Krause and Hong-fen Guo and J. L. Latouche and Chorh Chuan Tan and Nai-Kong V. Cheung and Michel Sadelain},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={619 - 626}
}
Most tumor cells function poorly as antigen-presenting cells in part because they do not express costimulatory molecules. To provide costimulation to T lymphocytes that recognize tumor cells, we constructed a CD28-like receptor specific for GD2, a ganglioside overexpressed on the surface of neuroblastoma, small-cell lung carcinoma, melanoma, and other human tumors. Recognition of GD2 was provided by a single-chain antibody derived from the GD2-specific monoclonal antibody 3G6. We demonstrate… CONTINUE READING

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