Antigen conformation determines processing requirements for T-cell activation.

  title={Antigen conformation determines processing requirements for T-cell activation.},
  author={Howard Z. Streicher and Ira Berkower and Marc Busch and Frank R. N. Gurd and Jay A Berzofsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={81 21},
We studied the difference in requirements for processing and presentation to a single T-cell clone of four different forms of the same epitope of sperm whale myoglobin--namely, on the native protein, on two conformationally altered forms of the protein, or as a 22-residue antigenic peptide fragment. The T-cell clone was I-Ed-restricted and specific for an epitope on the CNBr fragment 132-153 involving Lys-140. As inhibitors of macrophage processing of antigen, we used several agents that… CONTINUE READING